Year of entry: 2017
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- Degree awarded
- 3-4 years PhD, 1-2 years MPhil
- Entry requirements
- Applicants are expected to hold, or about to obtain, an Upper Second class Honours degree (or equivalent) in a related subject area. A Lower Second class Honours degree may be considered if applicants also hold a Masters degree with a Merit classification.
- Contact email
- Contact telephone
- +44 (0)161 275 5608
- How to apply
On the online application form, select PhD or MPhil for this programme and follow the instructions on our How to Apply page.
Applications must be submitted online well in advance of your anticipated start date (6 weeks for home/EU, 12 weeks for overseas). We cannot accept late applications without prior agreement via the Doctoral Academy.
April 2017 - submission no later than 15 February 2017
September 2017 - submission no later than 15 July 2017
April 2017 - submission in January 2017
September 2017 - submission no later than 1st June 2017
|Full-time||Part-time||Full-time distance learning||Part-time distance learning|
Research in the Centre for Musculoskeletal Research (CfMR) is undertaken by established groups and independent researchers investigating genetic and epidemiological aspects of musculoskeletal conditions.
- rheumatoid arthritis (RA)
- osteoarthritis (OA)
- psoriatic arthritis (PsA)
- juvenile idiopathic arthritis (JIA)
- systemic lupus erythematosus (SLE)
- myositis and scleroderma (Sc).
We have a strong track record of training students, and all of our senior staff have a hands-on approach to supervision.
We have a comprehensive programme of training and mentorship directed at all levels of career development. For postgraduate research students, we provide in-house training in generic lab skills, biostatistics and epidemiology.
Postgraduate research students are encouraged to take part in patient/public engagement and involvement activities (PPE/I) to discuss their research with members of the general public and patients.
Examples of research in genetics and genomics include the following.
- Identification and characterisation of genetic variants that influence susceptibility to rheumatological conditions including RA, JIA and PsA.
- Identification and characterisation of genetic and epigenetic variants that influence treatment response to methotrexate and/or biological therapy in rheumatological conditions including RA, JIA and PsA.
- Identification and characterisation of genetic/genomic variants that influence severity of rheumatological conditions. Investigating the function of genetic variants to refine the associated regions, and highlight likely causal variants, in loci with large, genetically intractable associations.
- Identifying key pathways involved in inflammation to identify novel targets to develop new drugs.
- Using stratified medicine and systems biology approaches to develop predictive and pharmacodynamics markers of treatment response.
- Characterising regulatory elements and causal mechanisms by which genetic variation contributes to phenotype.
- Applying gene expression profiling to predict treatment response in patients with RA.
- Undertaking longitudinal observational studies, case control studies and intervention studies.
- Investigating the co-morbidities associated with inflammatory musculoskeletal disorders and their impact on quality of life and mortality.
- Investigating environmental and genetic risk factor for developing RA, JIA and PsA.
- Hosting national databases and monitoring drug safety (i.e. pharmacoepidemiology) in RA, JIA and SLE.
- Using of big data (eg CPRD) to address relevant epidemiological questions.
- Intervention studies of devices and the development of new models of outcome in osteoarthritis.
- Investigating and predicting long-term outcomes in patients with JIA and RA including pain, quality of life, and worker-productivity loss.
- Investigating the pathophysiology, epidemiology, measurement and treatment of systemic sclerosis and primary Raynaud's phenomenon.
- Using e-health data to investigate changes in disease activity over time.
- Investigating adherence to treatment in patients with RA.
About our PhD and MPhil degrees
PhD/MPhil programmes are based on individual research projects that last three to four years (PhD) or one to two years (MPhil), working with a specific Primary Supervisor and Co-Supervisor(s).
Applicants are specifically matched with a Primary Supervisor and individual project based on their research interests and background.
Training and development
All of our postgraduate research students attend the Doctoral Academy Training Programme delivered by the Centre for Academic and Researcher Development (CARD).
The programme provides key transferable skills in areas such as commercial awareness, academic writing and public engagement. This training equips our postgraduates with the tools to progress beyond their research degree into influential positions within academia, industry and consultancy.
The emphasis is on enhancing skills critical to developing early-stage researchers and professionals, whether they relate to effective communication, disseminating research findings and project management skills.
See the training and development page for more information.
For entry in the academic year beginning September 2017, the tuition fees are as follows:
- PhD (full-time)
UK/EU students (per annum): Standard £4,195, Low £8,250, Medium £14,500, High £19,500
International students (per annum): Standard £21,000, Low £23,000, Medium £28,500, High £33,500
- PhD (part-time)
UK/EU students (per annum): Standard £2,098, Low £4,125, Medium £7,250, High £9,750
International students (per annum): Standard £10,500, Low £11,500, Medium £14,250, High £16,750
Search for a project
Use our database to find a research project by subject area, supervisor or funding type.
Find out about the research community, facilities and training delivered by our Doctoral Academy.