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Past research project examples – Tissue Engineering for Regenerative Medicine MRes

These are some of the research projects previously undertaken by students on our Tissue Engineering for Regenerative Medicine MRes.

 

Project titleSupervisor
Control of proliferation in human pancreatic endocrine progenitor cell lines M Dunne/K Cosgrove
Stem cell gene therapy for MPS IIIA disease F Wilkinson/B Bigger
Inkjet Printing Cell Sheets for ENT Surgical Applications B Derby/T Woolford
Cellular Scaffolds for Human Pancreatic Progenitor Cells and Beta-Cell Regeneration: for Diabetes Research Downes/Blandford/Dunne/Cosgrove
The role of fibrocytes in determining the degree of scarring/remodelling in the airways following allergen exposure S Herrick
Developing a tissue-engineered airway model using electrospun scaffolds S Herrick/J Gough
In vitro degradation of electrospun Poly(ε-caprolactone)/Poly(vinyl phosphonic acid-co-acrylic acid) scaffolds for bone regeneration S Downes
Investigating the mechanisms by which the inflammation-associated protein TSG-6 mediates cartilage protection and repair C Milner/A Day
Molecular descriptors for the fibroblast-myofibroblast phenotypic transition N Tirelli/F Cellesi
Investigating the role of N-cadherin in mouse ES cell self-renewal C Ward
Effect of degenerate IVD niche, specifically the cytokine milieu, on MSC differentiation to Intervertebral Disc Cells: impliatons for IVD regeneration J Hoyland/S Richardson
Characterization of periodontal ligament fibroblasts - do they have osteogenic and chondrogenic potential? H Devlin/J Hoyland
Developing Xenopus as a model to study neural development and regeneration K Dorey
Do plasma membrane calcium pump isoforms 1 and 4 have differential roles in pathological cardiac remodelling? E Cartwright
Evaluating 3D neural cell growth in peptide hydrogels A Saiani/G Terenghi
Characterization and directed differentiation of embryonic cranial neural crest cells grown in vitro N Bobola
Potential for in vivo training and experience Stem cell gene therapy for MPS IIIB Brian Bigger, Alex Langford-Smith
Scarring/remodelling in the airways following allergen injury Sarah Herrick, Sara Namvar
Targeting PMCA4 protein to enhance the protective effects of iPS derived cardiomyocytes Dr Delvac Oceandy, Dr Tamer Mohamed
Developing a tissue-engineered airway model using electrospun scaffolds Julie Gough, Sarah Herrick
Development of in vitro model systems to study the anti-inflammatory effects of MSCs degenerate intervertebral tissue Judith Hoyland, Steve Richardson
Novel electrospun scaffold morphologies for cell therapy: applications in the treatment of diabetes Sandra Downes, Karen Cosgrove
Human hair follicle stem cells: expression and function of ATP-binding cassette transporters Iain Haslam, Ralf Paus
Comparison of the differentiation potential of patient-matched bone marrow and adipose-derived mesenchymal stem cells seeded on biomaterials Stephen Richardson, Judith Hoyland
Knock-down of heparan sulphate in mesenchymal progenitor cells to investigate co-receptor function Catherine Merry (Materials),Cay Kielty (FLS)
Corneal Repair and Regeneration by Stem Cell Autografting Sue Shawcross, Chantal Hillarby
Peptide hydrogel for 3D culture of adult stem cells and neuronal cells Alberto Saiani, Giorgio Terenghi
Unravelling mechanisms of liver fibrosis for therapeutic and diagnostic strategies Karen Piper Hanley
Regenerating peripheral nerves - subpopulation selection of adipose derived stem cells influences differentiation to Schwann cells Adam Reid, Alessandro Faroni
The Pathology of encapsulating peritoneal sclerosis in long term dialysis patients Sarah Herrick; Mike Sherratt; Angela Summers
Dissecting the fibroblast-myofibroblast transition: role of mechanical and inflammatory stimuli Nicola Tirelli, Francesco Cellesi
Identification of novel annulus fibrosus cell phenotypic markers and evaluation of marker genes to identify mesenchymal stem cell differentiation Judith Hoyland, Stephen Richardson
Molecular structure and nanomechanical properties of the extracellular matrix of tissue engineered intervertebral disc tissue Judith Hoyland, Mike Sherratt