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Endocrine diseases

Thousands of people around the world suffer from endocrine diseases.

Often life-threatening, these diseases affect the body’s hormone producing systems. Their effects can be devastating.

Understanding and diagnosing these diseases depends on the ability to accurately measure the hormone levels of patients.

University of Manchester researchers have developed unique antibodies to two important hormones, adrenocorticotrophic hormone (ACTH) and pro-opiomelanocortin (POMC).

These antibodies have now been developed into testing kits, which are used worldwide to diagnose, monitor and inform treatment decisions for patients.

Since 2008, more than six million ACTH tests incorporating our antibodies have been sold by Roche Diagnostics International Ltd.

In collaboration with Professor Anne White, doctors across the globe are now using these tests to diagnose hormone secreting tumours in their patients and to monitor treatment.

In another area, this has led to the identification of two previously unknown human syndromes, which has aided patient counselling and monitoring.

Associated organisations

"The work from Dr White's laboratory has revolutionised how these patients are evaluated."

Professor Hershel Raff / Professor of Medicine, Surgery and Physiology, Medical College of Wisconsin