Mobile menu icon
Mobile menu icon Search iconSearch
Search type
Image: Eye vision

Vision

Understanding one of our most valued senses

Vision is one of our most valued senses. Our vision researchers study it at all levels, from the molecular mechanisms of light detection to the complex brain processes that allow us to see.

We focus on revealing basic biological principles and engineering optimal systems for image analysis and artificial vision, in order to develop new ways to diagnose and treat conditions that disrupt vision.

Our breadth of expertise and close collaboration with the Manchester Royal Eye Hospital allows us to set ambitious objectives in vision research.

Our research spans a range of disciplines including:

  • molecular biology
  • biochemistry
  • genetics
  • cell physiology
  • anatomy
  • neuroscience
  • experimental psychology
  • psychophysics
  • optics
  • electrical engineering
  • information technology.

We have a proud history of fundamental discovery in vision research at the University, and patients have benefited from our pioneering work in the diagnosis and treatment of visual dysfunction.

Featured projects

See a selection of current research projects, which aim to make a positive impact on health and disease in the eye.

Vision beyond rods and cones

A Wellcome Trust investigator award, awarded to Professor Robert Lucas, is exploring how melanopsin photoreceptors can contribute to vision. His work has implications not only for our understanding of how we see, but also addresses the design of image capture and visual display technologies.

Age-related macular degeneration (AMD)

A concerted initiative by our researchers is driving forward our understanding of the molecular basis of AMD and how best to treat this condition, which represents the most common cause of sight loss in the developed world. This research is funded by the MRC and charities including The Macular Society and Fight for Sight.

 

Featured researchers

Dr Simon Clark

simon clark

Simon Clark is an MRC Career Development Fellow investigating the role of the complement system in the pathogenesis of age-related macular degeneration.

Read profile

Dr Hema Radhakrishnan

hema radhakrishnan

Hema Radhakrishnan is a Senior Lecturer in Optometry. She was awarded the Neil Charman medal, the College of Optometrist’s most prestigious award for research, for her pioneering work on ocular accommodation and collagen cross linking.

Read profile

Dr Timothy Brown

tim brown

Tim Brown is a BBSRC David Philips Fellow who studies how the retina and the brain’s internal circadian clock come together to control our most fundamental physiological processes.

Read profile

Dr Riccardo Storchi

riccardo storchi

Riccarro Storchi is a David Sainsbury NC3Rs fellow developing automated analyses of mouse spontaneous behaviour as an entirely non-invasive way of measuring their visual abilities.

Read profile

Case studies

Our discoveries about how the eye works are contributing to the development of new technologies and treatments.

Redesigning artificial lights to suit our biological needs

Disruption of the body clock and sleep-wake cycle, caused by exposure to unnatural light, can have a profound influence on health and wellbeing.

Neuroscientists at the University, led by Professor Rob Lucas, discovered a previously unknown light receptor responsible for a range of important subconscious responses. Their research established ways of predicting light's effect on these receptors.

Rob is now developing visual display technology (watch a short video) and working with lighting manufacturers and policymakers to produce international standards for light measurement, which can be used to improve lighting for human health and wellbeing in domestic, public and industrial settings.

Read more

Modulation of immune response as a therapy for AMD

Dr Simon Clark and colleagues study immune regulation in the human eye and how an underlying genetic predisposition leads to a common cause of blindness called age-related macular degeneration (AMD). Despite its prevalence in the older population, no treatments currently exist for the most common form of AMD.

By using unique human tissue resources available from the Manchester Eye Tissue Repository the team has made discoveries around how the complement system, part of a hosts innate immune system, drives the underlying pathogenesis of AMD.

Using this insight, they have designed complement-mediating therapeutics to treat AMD that are designed specifically for the delivery and efficacy in the human eye. Work funded by the Medical Research Council is currently underway around the preclinical work-up prior to the first phase of clinical trials.

 

 

Training and education

We are strongly committed to the training and education of our future scientists.

Contact

Dr Paul Warren
Email: paul.warren@manchester.ac.uk
Tel: +44 (0)161 275 7699