Mobile menu icon
Mobile menu icon Search iconSearch
Search type
Stroke

Stroke

.

Stroke is a leading cause of death and disability. Our research spans the translational pipeline from basic experimental biology and trials of healthcare interventions through to implementing findings into practice.

We focus on understanding mechanisms of neuroimmune and vascular dysfunction, how they contribute to acute cerebrovascular diseases, and the impact of these conditions.

We carry forward this knowledge to improve the process and outcomes of care and, ultimately, the quality of life for stroke survivors and their carers.

Our research is unique in combining life sciences, interdisciplinary clinical research and implementation science.

We cover all clinical subtypes of stroke (ischaemic and haemorrhagic) and include all stages of clinical care (hyperacute through to community) for people with stroke. We also have strong links to the Manchester Centre for Clinical Neurosciences.

Image: TBC

Areas of research activity

This interdisciplinary approach is underpinned by active patient, carer and public involvement and engagement.

Our research activity can be grouped into four categories:

 

Basic biology and pre-clinical science

Minimising brain damage after stroke

Promoting repair and recovery of function

  • Communication difficulties after stroke(aphasia)
    Principal investigators: Anna Woollams
  • Sensory and motor difficulties including vision and arm function
    Principal investigators: Ulrike Hammerbeck, David Howard (University of Salford)

Managing persisting disabilities and organising care

Image: TBC

Featured projects

See a selection of current research projects, which aim to make a positive impact on health and disease both nationally and globally.

Stroke connected health cities

Part of a £20 million Health North initiative, led by Dr Adrian Parry-Jones, stroke researchers are looking at using technology and data to improve the diagnosis and treatment of strokes across Greater Manchester.

Read more

Contribution of neuro-inflammation to cerebral ischaemia

Dr David Brough, Professor Stuart Allan, Professor Kostas Kostarelos and Professor Dame Nancy Rothwell are leading a MRC funded project investigating how inflammasomes contribute to brain injury after stroke. This project is also harnessing the power of nanotechnologies to interrogate mechanisms of inflammation and how they contribute.

OSCARSS

Organising Support for Carers of Stroke Survivors is a large cluster randomised controlled trial, process evaluation and economic study funded by the NIHR CLAHRC in partnership with Stroke Association led by Professor Audrey Bowen and Dr Emma Patchwood.

Read more

Image: TBC

Case studies

Our stroke research led to three successful REF2014 impact case studies around services for people with communication, cognition and swallowing difficulties, and the introduction of six month reviews for patients.

Improving stroke services

The ACT NoW study evaluated the effectiveness of speech and language therapy in stroke rehabilitation and is now being used in international guidelines for stroke recovery.

Read more

Helping stroke patients swallow

Our pioneering research led to the introduction of the world's first effective throat stimulation treatment for stroke patients with swallowing problems.

Read more

Improving health with assessment tool

A team at Manchester developed GM-SAT, a simple evidence based assessment tool which can be used to identify and address individuals’ long term, unmet post-stroke needs.

Read more

Featured researchers

Dr Ulrike Hammerbeck

Dr Ulrike Hammerbeck

Ulrike Hammerbeck is a physiotherapist and Stroke Association post-doctoral fellow investigating proximal arm recovery processes in the acute period after stroke.

Read profile

Dr Emmanuel Pinteaux

Emmanuel Pinteaux

Emmanuel Pinteaux has received a $1.5m (£1.2m) joint grant with the University of Kentucky from the National Institute of Health (USA) to explore Interleukin-1 alpha as a novel treatment for ischemic stroke.

Read profile

Dr Emma Patchwood

Emma Patchick

Emma Patchwood is a research psychologist in the CLAHRC GM. Her role includes implementing six month reviews of need after stroke for care home residents, and the OSCARSS carer study (featured above).

Read profile

Dr Paul Kasher

Paul Kasher

Paul Kasher is a translational neuroscience research fellow with expertise in the generation and characterisation of experimental models of neurological disease and recent recipient of a Stroke Association lectureship.

Read profile

Image: TBC

Patient and public involvement and engagement

Our research benefits from strong patient, carer and public involvement, and we regularly conduct public engagement activities around stroke science and art. Examples include:

ReaDySpeech

A feasibility randomised controlled trial for people with dysarthria, a disordered speech production which is a common symptom after stroke.

Read a blog by project lead Claire Mitchell about living with dysarthria.

OSCARSS research user group

An active user group of carers support the development of all aspects of the design and roll out of the OSCARSS study.

Watch a video about this project featuring members of the user group.

Stroke: Stories of the Self Through Art and Science

The Stroke Association and The University of Manchester ran a set of visual arts workshops and exhibitions at Manchester Central Library and Manchester Museum to tell Stroke survivors’ stories.

Read a blog by artist Elisa Artesero who facilitated the workshops.

Social responsibility in the medical teaching curriculum

Stroke, Self and Brain, a social responsibility project funded by the University in partnership with the Stroke Association, brought together stroke survivors with medical students for workshops to share knowledge and experience of the brain before and after stroke through the creation of original artworks.

Watch a video about the workshops.

Image: TBC

PhD opportunities

We are strongly committed to the training and education of our future scientists.

Contact

Professor Craig Smith
email:Craig.Smith-2@manchester.ac.uk


Tel+44(0)161 206 0623