Neuro oncology molecular imaging
The University's Positron Emission Tomography (PET) facilities are based at the Wolfson Molecular Imaging Centre (WMIC), on the site of the Christie Hospital.
WMIC offers researchers the chance to work within a fully equipped, unique facility with all the required regulatory approvals to conduct a broad range of PET-related research.
Two research-dedicated clinical PET scanners and one pre-clinical PET camera are all situated in the building, along with a 1.5T MRI scanner.
There are particular benefits for using these facilities in brain tumour research, including:
the HRRT (High Resolution Research Tomograph) is the clinical brain PET camera with the highest spatial resolution in the world;
- portfolio of tracers for brain tumour research:
- [15O]water to measure blood flow
- [18F]FDG to measure glucose utilisation
- [11C]methionine and [18F]Fluoro-DOPA for amino acid transport and metabolism
- [11C](R)-PK11195 and [18F]GE-180 for binding to the translocator protein 18kDa (TSPO)
- [11C]temozolomide to study brain tumour drug delivery
- [18F]FAZA to image hypoxia
- [11C]verapamil to study blood-brain barrier transport
- L-[1-11C]leucine to measure rates of protein synthesis;
- expertise in study design and data analysis;
- bench-to-bedside links due to in house pre-clinical imaging and MALDI mass spectrometry imaging;
- a strong imaging team, including clinical and non-clinical researchers.
Clinical research fellows
- Dr Zhangjie Su
- Dr Ibrahim Djoukhadar
- Dr Erjon Agushi
- Dr Daniel Lewis