Driven by the health needs of the population, our goal is to work in partnership with local and national stakeholders, including the NHS, to adopt a system-wide approach to the discovery, development and delivery of innovation in P4 medicine in immune-mediated inflammatory diseases.
Chronic inflammation underpins many common conditions including psoriasis, inflammatory arthritis, autoimmune connective tissue diseases and respiratory diseases such as asthma and chronic obstructive pulmonary disease.
In fact, it is thought that more than one in 20 people will develop a chronic inflammatory condition. This figure is set to rise as the population ages, resulting in a huge burden in terms of healthcare costs.
Mechanisms of inflammation are shared between conditions and they may also respond to similar therapies.
Understanding the similarities and differences underlying inflammation will allow us to target treatments to patients most likely to benefit from them.
We attract significant investment to support P4 (predict, prevent, personalised, participatory) and inflammation medicine research in Manchester.
Major research activities
Skin disorders are common, making up 20% of all GP consultations. We are home to one of the most active and comprehensive centres for dermatology research in the world. Our research addresses questions that arise from patient care, so is therefore directly translatable to both prevent and better manage skin disease using the principles of P4 medicine; predict, prevent; personalise and participate.
Musculoskeletal diseases account for nearly one third of disabilities in the UK. What causes these conditions? How can we treat them and how can we target the right drugs to the right patients? And, can we also develop new therapies to treat diseases where few treatment options are currently available?
Respiratory diseases are the second most common cause for hospital admission in the UK and every five minutes somebody dies from lung disease. Chronic inflammatory conditions of the lung such as chronic obstructive pulmonary disease (COPD) and asthma affect millions. Yet we still don’t know what causes them, how best to diagnose them and how to select the best treatments for individual patients.
See a selection of current research projects, which aim to make a positive impact on health and disease both nationally and globally.
Manchester Biomedical Research Centre (BRC)
The NIHR Manchester BRC connects world-leading researchers based at The University of Manchester and three NHS Trusts in Greater Manchester, with a joint vision to drive forward the transformation of scientific breakthroughs into life-saving treatments and care for patients.
MASTERPLANS MRC-funded stratified medicine award
The MASTERPLANS consortium will work to identify factors that predict which patients respond well on any particular lupus treatment.
MATURA MRC-funded stratified medicine award
Supported in partnership with Arthritis Research UK, the MATURA consortium aims to enable early, effective treatment and improve the cost-effectiveness of care for around 500,000 people in the UK who suffer from the painful inflammatory condition rheumatoid arthritis.
PSORT MRC-funded stratified medicine award
The PSORT consortium aims to use existing knowledge about psoriasis, both clinical and scientific, and an unparalleled patient base, coupled to involvement of patient organisations and state-of-the-art investigative tools, to develop tests that can be used in the clinic to help direct personalised treatments.
IMIDBio-UK MRC-funded biobank initiative
The University of Manchester is part of a national consortium which has been awarded a £1.7 million grant to create the world’s largest Immune-Mediated Inflammatory Disease (IMID) Biobank, in excess of 40,000 patients.
Professor Anne Barton
Professor of Rheumatology, NIHR Senior Investigator
Anne is Professor of Rheumatology at The University of Manchester, with an honorary position as a consultant in rheumatology at Manchester University NHS Foundation Trust. She is also Musculoskeletal Theme Lead for the NIHR Manchester BRC.
Professor Ian Bruce
Professor of Rheumatology, NIHR Senior Investigator
Ian is the Medical Director of the NIHR Manchester Wellcome Trust Clinical Research Facility and Centre Academic Lead for the NIHR Translational Research Partnership in Joint and Related Inflammatory Diseases. He is also Director of the NIHR Manchester BRC.
Professor Christopher Griffiths
Foundation Professor of Dermatology, NIHR Senior Investigator
Chris is Foundation Professor of Dermatology at The University of Manchester and Consultant Dermatologist at Salford Royal NHS Foundation Trust.
Professor Angela Simpson
Professor of Respiratory Medicine
Angela is Head of the Division of Infection, Immunity and Respiratory Medicine at The University of Manchester and an honorary consultant respiratory physician at University Hospital of South Manchester.
Training future scientists and doctors
We are committed to providing the highest quality teaching and research training to help develop the next generation of clinical and basic scientists.
Dr Anu Suokas, Strategic Funding Manager
tel: +44 (0) 161 306 0562