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Antibody attacking bacterium. Immunoglobulin, 3d view

Immune tolerance

Immune tolerance

Our immune system has the difficult task of defending the body against potential threats while recognising and not attacking host molecules. In autoimmune diseases this tightly controlled system breaks down and the immune system targets the body’s own organs and tissues.

Autoimmune diseases affect up to 3% of the population and examples include rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, psoriasis, myositis, systemic sclerosis, systemic lupus erythematosus and inflammatory bowel disease.

By working closely with basic scientists, immunologists and a variety of clinical disciplines, we aim to increase our understanding of how immune dysregulation causes disease so that scientific discoveries can be translated into the clinic to ultimately improve the management of these conditions.


Dr Matthew Hepworth

Deputy TBC