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COVID-19 activity

Our COVID-19 research

Our COVID-19 research

Immuno-phenotyping of patient samples following COVID-19 infection allows researchers to understand the immune response to the disease and predict disease severity.

The LBIII has formed an Coronavirus Immune Response and Clinical Outcomes (CIRCO) team with all major hospitals in Manchester (Manchester University NHS Foundation Trust (MFT), Salford Royal NHS Foundation Trust, and North Manchester General Hospital). We are working together to longitudinally immuno-phenotype patient samples to understand the nature of the immune response to the SARS-CoV-2 virus, which is responsible for the current COVID-19 pandemic.

The data from this study has already provided insights to the immunological phenotypes associated with disease severity.

View the article now (pdf on BioRxiv)

In some patients the immune system over-reacts to the virus, inducing a cytokine storm resulting in ARDS (acute respiratory distress syndrome) and the cause of most critical care admissions. Immuno-phenotyping will enable us to identify early markers in patients who are likely to be admitted to intensive care, allowing earlier intervention.

We are also beginning to investigate the potential longer-term effects of the virus on the lung and other organs in the body such as the gut and kidney.

More on our blog

Read our blog for further updates and insight on our work on COVID-19.

Expert coverage and commentary

Our academics provide insight across a range of media and engagement opportunities. We have highlighted recent contributions related to COVID-19 by our academics.

Thomas Blanchard

Title: Significant outbreak likely
Outlet: BBC Radio Manchester
Date: 3 March 2020

 

Title: Response to coronavirus
Outlet: BBC Radio 5 live
Date: 9 March 2020

 

Title: The role of the immune system in fighting COVID-19, and the importance of harnessing it’s mechanisms to help treat the disease
Outlet: The Conversation
Date: 11 May 2020

 

Title: COVID-19
Outlet: BBC Radio Manchester
Date: 21 July 2020

Sheena Cruickshank

Title: How to boost your immune system to avoid colds and coronavirus
Outlet: The Guardian
Date: 8 March 2020

 

Title: Monkeys Develop Protective Antibodies to SARS-CoV-2
Outlet: The Scientist
Date: 17 March 2020

 

Title: How to boost your immune system to avoid colds and coronavirus
Outlet: The Sun
Date: 25 March 2020

 

Title: Partly false claim: A list of eight coronavirus-related “facts”
Outlet: Reuters
Date: 26 March 2020

 

Title: Ways people can ensure their immune systems are in the best possible shape to fight off infections such as coronavirus
Outlet: Outside online
Date: 27 March 2020

 

Title: Q&A: How do vaccines work?
Outlet: The Times and The Sunday Times
Date: 10 April 2020

 

Title: Can we learn anything from the plague village of Eyam which we could apply to the coronavirus pandemic
Outlet: BBC News
Date: 22 April 2020

 

Title: Immunology in a pandemic
Outlet: Facebook Live
Date: 29 April 2020

 

Title: The role of the immune system in fighting COVID-19, and the importance of harnessing it’s mechanisms to help treat the disease
Outlet: The Conversation
Date: 11 May 2020

 

Title: Prof Cruickshank talks antibody testing would be best used alongside track and trace
Outlet: LBC Radio
Date: 21 May 2020

 

Title: Coronavirus: how T cells are involved and what it might mean for vaccine development
Outlet: The Conversation
Date: 11 June 2020

 

Title: Can our immune system 'remember' the coronavirus? Scientists hope so
Outlet: NBC News
Date: 2 July 2020

 

Title: One vaccines to beat COVID-19, Sars?
Outlet: Conversation
Date: 10 July 2020

 

Title: COVID-19
Outlet: Conversation Indonesia
Date: 20 July 2020

Dan Davis

Title: Q&A on COVID-19, answering questions from the public (featuring five experts)
Outlet: The Cosmic Shambles
Date: 5 April 2020

 

Title: Are you immune if you have had coronavirus?
Outlet: Channel 4
Date: 7 April 2020

 

Title: What causes a fever, and how the body uses the rise in temperature to fight infection?
Outlet: New Scientist
Date: 8 April 2020

 

Title: Immunology in a pandemic
Outlet: Facebook Live
Date: 29 April 2020

 

Title: Drug firms are racing to calm the cytokine storm
Outlet: The Times
Date: 15 May 2020

 

Title: Immunology and COVID-19
Outlet: Hay Festival
Date: 26 May 2020

 

Title: Coronavirus: how T cells are involved and what it might mean for vaccine development
Outlet: The Conversation
Date: 11 June 2020

 

Title: Lockdown Lecture: Dan Davis
Outlet: University of Manchester Lockdown Lecture
Date: 15 June 2020

 

Title: COVID-19 Antibodies
Outlet: Newsweak Women's Health
Date: 18 June 2020

 

Title: Sleep and the immune response
Outlet: MSN News
Date: 18 June 2020

 

Title: Dexamethasone: the coronavirus drug 91 years in the making
Outlet: The Times
Date: 21 June 202

 

Title: COVID-19 Vaccines
Outlet: The Times
Date: 16 July 2020

 

Title: COVID-19 Vaccine
Outlet: Channel 5 News
Date: 16 July 2020

 

Title: Coronavirus drug: how interferon can be traced back to a meeting of minds in 1956
Outlet: The Times
Date: 21 July 2020

Tim Felton

Overview: Tim, our Clinical Lead for all Manchester University NHS Foundation Trust COVID19-related research studies, spoke about the coronavirus clinical trials taking place at our Trust.
Outlet: BBC Northwest
Date: 22 April 2020

 

John Grainger

Title: Immunology in a pandemic
Outlet: Facebook Live
Date: 29 April 2020

 

 

Tracy Hussell

Overview: Talking about the best ways to beat COVID-19
Outlet: Channel 4 News and Sky News
Date: 31 March 2020

 

Title: Top scientists racing to pinpoint who will be hit hardest by coronavirus
Outlet: Manchester Evening News (MEN)
Date: 05 April 2020

 

Title:  Talking about individual reactions to COVID-19
Outlet: LBC Radio
Date: 7 April 2020

 

Title: Immunology in a pandemic
Outlet: Facebook Live
Date: 29 April 2020

 

Elizabeth Mann

Overview: Talking about the best ways to beat COVID-19
Outlet: Channel 4 News and Sky News
Date: 31 March 2020

 

Title:  Top scientists racing to pinpoint who will be hit hardest by coronavirus
Outlet: Manchester Evening News (MEN)
Date: 5 April 2020

 

Overview: Elizabeth explained the work being carried out to understand why some people show a much stronger immune response than others, which contributes to the severity of COVID-19.
Outlet: BBC Radio 5
Date: 11 April 2020

 

Title:  Our entire way of working has changed
Outlet: The Biologist
Date: 20 April 2020

 

Title:  Testing for COVID-19
Outlet: BBC Radio 4
Date: 28 March 2020

 

Title:  Immunology in a pandemic
Outlet: Facebook Live
Date: 29 April 2020

 

Title: Guest speaker on BBC Radio
Outlet: BBC Radio Sussex
Date: 10 June 2020

Madhvi Menon

Overview: Talking about the best ways to beat COVID-19
Outlet: Channel 4 News and Sky News
Date:31 March 2020

 

Title:  Top scientists racing to pinpoint who will be hit hardest by coronavirus
Outlet: Manchester Evening News (MEN)
Date: 5 April 2020

 

Title: Our entire way of working has changed
Outlet: The Biologist
Date: 20 April 2020

 

Title: Immunology in a pandemic
Outlet: Facebook Live
Date: 29 April 2020

 

 

Nancy Rothwell

Overview: The World Tomorrow Podcast
Outlet: Sky News
Date: 21 July 2020