Evolution, systems and genomics
This domain is concerned with the understanding of gene and genome function, structure, sequence variation and long-term evolution.
We use highly interdisciplinary experimental, statistical and computational methods.
The domain encompasses the broad scope of genetic diversity from viruses and bacteria, fungi and protozoans, plants and animals – including humans. Genetic and genomic work includes neonatal testing through the women and children domain of the Manchester Academic Health Science Centre (MAHSC) and working with data from millions of completed genomes.
We use massively parallel computing infrastructures for genome assembly, annotation and analysis, and develop algorithms and computer code for data analytics.
The domain is not only concerned with basic science. It also considers the practical applications of this understanding as it relates to issues of global importance such as the spread of antibiotic resistance, the impact of human genetic variation, and the underlying causes of disease. Methodological approaches range from studies on the control and functions of individual genes to models of how whole systems operate and evolve.