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Gene expression, chromatin and signalling

Understanding the mechanisms of gene expression

Unlocking development, disease and evolution

Changes in gene expression underlie development, disease and evolution. We aim to understand the mechanisms that instruct these changes and how they impact on human developmental disorders and diseases such as cancer, fibrosis and arthritis.

Gene expression is a complex and dynamic process, controlled by a variety of signals across space and time, giving rise to intricate and changing expression patterns.

The overall aim of our research in this area is to understand the molecular basis to these events and their significance in the context of organismal homeostasis, development and disease. We are studying how gene transcription is initiated and terminated and how post-transcriptional mechanisms impact on this.

A combination of gene-centric and genome-wide approaches are used and, in the latter, the importance of long range genomic interactions and 3D folding of the chromatin are a major theme in our research.

A variety of model organisms, including yeast, Dictostelium, frogs, zebrafish and mice, are used alongside research directly in human cells and tissue.

 

Major research activities

Featured researchers

Dr Stephen Eyre PhD

Senior Research Fellow

Dr Stephen Eyre

Stephen Eyre’s research has been fundamental to our current understanding of the genetics of rheumatoid arthritis. Most recently his work has demonstrated how regulatory genetic elements implicated in disease susceptibility can act over long distances, implicating likely causal genes and biological pathways that drive rheumatoid arthritis.

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Dr Gino Poulin PhD

Lecturer

Dr Gino Poulin

Gino Poulin’s research seeks to understand how signalling events impact on the epigenome to regulate ageing, stress responses, and transgenerational inheritance. His latest work, in collaboration with Alan Whitmarsh’s lab, revealed that the mitochondria signals to the nucleus to alleviate oxidative stress via the respiratory enzyme CLK–1.

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Researcher in the lab

Contact

Academic enquiries

Contact: Andrew Sharrocks

Administrative enquiries

Contact: Yasmin Moore