Cardiovascular, metabolic and nutritional sciences
Cardiovascular disease, stroke, nutritional and metabolic disease will account for the largest proportion of deaths this century. This will be chiefly driven by the explosive worldwide increase in the prevalence of obesity and diabetes.
This domain adopts a multidisciplinary, integrative approach to these problems, grounded in mechanistic cellular and molecular studies of the heart and circulation, the control of energy balance, and the endocrine and metabolic systems.
We conduct experimental medicine studies, clinical trials and implementation science with our NHS partners in the cardiovascular domain of the Manchester Academic Health Science Centre (MAHSC), and population-based studies of genetic, environmental, and behavioural determinants of risk.
The domain has an international outlook, collaborating effectively with colleagues in the low- and middle-income countries suffering the most dramatic increases in disease prevalence. Our work spans the lifecourse from developmental influences on subsequent health trajectories to studies of ageing and disease risk.
The common thread running through research in the domain is to deliver novel therapies by improving our mechanistic understanding of health and disease.