There is clear evidence in both animal models and patient studies that circadian clock dysfunction contributes to the incidence and severity of many disease states, including inflammation and metabolic syndrome.
Despite this, coherent translational research programmes focused on clock biology have yet to be realised. Research and clinical expertise in Manchester is now bridging this gap.
Using model organisms, in vitro and computational approaches our PIs are uncovering mechanistic links between the circadian clockwork and our physiology to reveal new and exciting approaches for drug development and therapy.
Specific research strengths include inflammation, metabolic and cardiovascular disease, diabetes, tissue fibrosis, and cancer. Critically, we can rapidly progress basic research breakthroughs into a clinical setting, with ongoing trials in inflammatory arthritis, type-2 diabetes, and asthma.
David Bechtold (Lead)
Circadian controls of behaviour, energy metabolism and cardiovascular physiology.
Neural circuit mechanisms underlying circadian and light-dependent physiological responses.
Immune regulation during parasitic helminth infection.
RCUK Future Leaders Research Fellow.
Exploring mechanisms underlying circadian control of immunity.
Understanding how daily rhythms in the intestinal immune system regulate responses to the microbiota and infection.
Tissue Homeostasis, collagen dynamics, and fibrosis.
Circadian clock mechanisms and seasonal timekeeping.
Circadian timing mechanisms in age-related diseases.
Modelling and inference in biological systems.
Nuclear receptor and circadian clock biology regulation of inflammation and energy metabolism.
Circadian clocks in breast biology.
Influence of gene expression timing and dynamics on cell fate decisions in the early embryo.
Molecular mechanisms underlying breast cancer progression and metastasis.
Timing, robustness and coordination of cell identity decisions underpinning tissue morphogenesis.
Professor of Molecular Pathology.
Professor of Inflammatory Disease.
Inflammatory and immune cellular signalling networks.
The mechanisms of signal-dependent transcriptional control.
Other major biological timing research activity
Brain, behaviour and environmental response
Our research examines how clocks structure within the brain, including master clock housed within the suprachiasmatic nuclei (SCN) read these environmental signals to regulate behaviour and physiology on a circadian and seasonal scale.
Clinical translation and multi-morbidity
Driving research in clock genes forward to address the gap in biomedical research and clinical practice.