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Internal homeostasis and clock mechanisms

Internal homeostasis and clock mechanisms

Circadian rhythms in physiology and disease

There is clear evidence in both animal models and patient studies that circadian clock dysfunction contributes to the incidence and severity of many disease states, including inflammation and metabolic syndrome.

Despite this, coherent translational research programmes focused on clock biology have yet to be realised. Research and clinical expertise in Manchester is now bridging this gap.

Using model organisms, in vitro and computational approaches our PIs are uncovering mechanistic links between the circadian clockwork and our physiology to reveal new and exciting approaches for drug development and therapy.

Specific research strengths include inflammation, metabolic and cardiovascular disease, diabetes, tissue fibrosis, and cancer. Critically, we can rapidly progress basic research breakthroughs into a clinical setting, with ongoing trials in inflammatory arthritis, type-2 diabetes, and asthma.

Principal investigators

David Bechtold (Lead)
Circadian controls of behaviour, energy metabolism and cardiovascular physiology.

Tim Brown
Neural circuit mechanisms underlying circadian and light-dependent physiological responses.

Kathryn Else
Immune regulation during parasitic helminth infection.

Jean-Michel Fustin
RCUK Future Leaders Research Fellow.

Julie Gibbs
Exploring mechanisms underlying circadian control of immunity.

Matthew Hepworth
Understanding how daily rhythms in the intestinal immune system regulate responses to the microbiota and infection.

Karl Kadler
Tissue Homeostasis, collagen dynamics, and fibrosis.

Andrew Loudon
Circadian clock mechanisms and seasonal timekeeping.

Qing-Jun Meng
Circadian timing mechanisms in age-related diseases.

Magnus Rattray
Modelling and inference in biological systems.

David Ray
Nuclear receptor and circadian clock biology regulation of inflammation and energy metabolism.

Charles Streuli
Circadian clocks in breast biology.

Associated researchers

Hilary Ashe
Influence of gene expression timing and dynamics on cell fate decisions in the early embryo.

Chiara Francavilla
Molecular mechanisms underlying breast cancer progression and metastasis.

Shane Herbert
Timing, robustness and coordination of cell identity decisions underpinning tissue morphogenesis.

Judith Hoyland
Professor of Molecular Pathology.

Tracy Hussell
Professor of Inflammatory Disease.

Pawel Paszek
Inflammatory and immune cellular signalling networks.

Andrew Sharrocks
The mechanisms of signal-dependent transcriptional control.