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Clinical translation and multi-morbidity

Clinical translation and multi-morbidity

Clinical translation and multi-morbidity

Our goals are to exploit timing as a new dimension in biology and medicine to identify new fundamental design principals with potential application to health, wealth, and treatment of human populations world-wide.

The award of the Nobel Prize in Physiology or Medicine in 2017 for the discovery of the clock genes was recognition of the importance of the field, but thus far there has been a negligible impact on biomedical research, or clinical practice. In Manchester, we have a critical mass of basic, clinical, and computational investigators able to drive clinical adoption forward. We also benefit from close proximity to the largest research hospital complex in the UK outside London.

Principal investigators

John Blaikley
Rhythms in fibrosis.

Hannah Durrington
Biological Timing mechanisms in asthma. Translational studies.

Louise Hunter
Glucocorticoids and the circadian clock in the control of metabolism.

Gareth Kitchen
Circadian rhythms in critical care, clock control of macrophage function.

David Ray
Nuclear receptor and circadian clock biology regulation of inflammation and energy metabolism.

Martin Rutter
Sleep/chronotype and cardiometabolic disease.