Our goals are to exploit timing as a new dimension in biology and medicine to identify new fundamental design principals with potential application to health, wealth, and treatment of human populations world-wide.
The award of the Nobel Prize in Physiology or Medicine in 2017 for the discovery of the clock genes was recognition of the importance of the field, but thus far there has been a negligible impact on biomedical research, or clinical practice. In Manchester, we have a critical mass of basic, clinical, and computational investigators able to drive clinical adoption forward. We also benefit from close proximity to the largest research hospital complex in the UK outside London.
Rhythms in fibrosis.
Biological Timing mechanisms in asthma. Translational studies.
Glucocorticoids and the circadian clock in the control of metabolism.
Circadian rhythms in critical care, clock control of macrophage function.
Nuclear receptor and circadian clock biology regulation of inflammation and energy metabolism.
Sleep/chronotype and cardiometabolic disease.
Other major biological timing research activity
Brain, behaviour and environmental response
Our research examines how clocks structure within the brain, including master clock housed within the suprachiasmatic nuclei (SCN) read these environmental signals to regulate behaviour and physiology on a circadian and seasonal scale.
Internal homeostasis and clock mechanisms
Using model organisms, in vitro and computational approaches our PIs are uncovering mechanistic links between the circadian clockwork and our physiology to reveal new and exciting approaches for drug development and therapy.