The ability to respond to and time rhythmic fluctuations in the environment (such as light, colour, temperature, food availability) is central to survival for most organisms on the planet.
Our research examines how clocks structure within the brain, including master clock housed within the suprachiasmatic nuclei (SCN) read these environmental signals to regulate behaviour and physiology on a circadian and seasonal scale.
By combining state-of-the-art neurophysiological techniques – with in vivo and ex vivo imaging – and comprehensive physiological phenotyping facilities, we are mapping out the neural networks which allow us to time our world.
Tim Brown (Lead)
Neural circuit mechanisms underlying circadian and light-dependent physiological responses.
Dean's Prize Research Fellow.
Circadian controls of energy metabolism.
Circadian clock mechanisms and seasonal timekeeping.
Regulation of biological timing by light.
Fight for Sight Research Fellow.
NC3Rs Research Fellow.
Other major biological timing research activity
Clinical translation and multi-morbidity
Driving research in clock genes forward to address the gap in biomedical research and clinical practice.
Internal homeostasis and clock mechanisms
Using model organisms, in vitro and computational approaches our PIs are uncovering mechanistic links between the circadian clockwork and our physiology to reveal new and exciting approaches for drug development and therapy.