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Image: Blood vessel system of a heart

Cardiovascular, endocrine and metabolic sciences

Advancing our understanding of health and disease

Translational research with a global reach

Cardiovascular disease, stroke, nutritional and metabolic diseases will account for the largest proportion of deaths this century – driven by the explosive worldwide increase in the prevalence of obesity and diabetes.

This research domain unites the diverse expertise of more than 200 researchers working across closely-linked scientific areas and diseases to tackle these global problems, making the best use of our excellent links with NHS partners and access to one of the largest populations of any academic health science system.

Our research spans the life course; from developmental influences on subsequent health trajectories through to studies of ageing and disease risk.

Our research spans the life course; from developmental influences on subsequent health trajectories through to studies of ageing and disease risk.

We have three major areas of research activity:

Adopting a multidisciplinary, integrative approach, our research is grounded in mechanistic, cellular and molecular studies of the heart and circulation, the control of energy balance, and endocrine and metabolic systems.

Our strong track record in basic science and excellent clinical links positions us well to conduct both ‘bench to bedside’ research but also ‘reverse translation’ from clinical observations to biological insights.

Our size and diversity of expertise means we are able to conduct experimental medicine studies, clinical trials and implementation science, as well as population-based studies of genetic, environmental, and behavioural risks.

The common thread running through all of our research is to deliver novel therapies by improving our mechanistic understanding of health and disease.

The domain is led by Professor Bernard Keavney.

 
Histology of a gland

Our research attracts investment

We are a major beneficiary of Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council (BBSRC), British Heart Foundation (BHF) and Wellcome Trust funding.

We have been successful in attracting numerous external personal awards over the last couple of years including BHF Chairs, Wellcome Investigators in Science, Stroke Association Reader and Lectureships and numerous senior and intermediate fellowships from MRC, BBSRC, BHF, NIHR, and Wellcome Trust.

Several programme grants are held by our affiliates and the prestigious BHF 4 year PhD programme was renewed in 2016.

£145m
£61m
£64m

Impact at home and abroad

Being based in Manchester, we work within one of the largest populations of any academic health science system.

Devolution of the health and social care budget in the region has the potential to transform how cardiovascular needs are treated here, and we are ideally placed to be at the forefront of these developments.

The domain has a strong international dimension, and conducts a great deal of research in collaboration with colleagues in low- and middle-income countries that have seen significant increases in disease prevalence.

By bringing together our strengths, we have a unique opportunity to tackle some major problems…

By bringing together our strengths in genetics, physiology, clinical research and epidemiology, we have a unique opportunity to tackle some of the major problems associated with irregular blood pressure (hypertension, stroke and atherosclerosis), heart failure and arrhythmias.

Training future scientists and doctors

Our multidisciplinary and highly collaborative environment is ideal to develop the next generation of researchers needed to deliver improved healthcare outcomes for the region and establish Manchester as a internationally-renowned centre of research excellence.

Student studying model heart

Contact

Research enquiries

Professor Bernard Keavney

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